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Human CD28/TP44  Antibody

All CD28 Reagents

Reactivity: Human  
Application: 
11524-R007-C-25
11524-R007-C-100
25 Test 
100 Tests 
Add to Cart
  • Slide 1
Reactivity: Human  
Application: ELISA  
11524-MM06-50
11524-MM06-200
11524-MM06-100
11524-MM06-1
50 µg 
200 µg 
100 µg 
1 mg 
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    Reactivity: Human  
    Application: FCM  Func/A  
    11524-H001-500
    11524-H001-100
    11524-H001-1
    500 µg 
    100 µg 
    1 mg 
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    • Slide 1
    • Slide 1
    • Slide 1
    Reactivity: Human  
    Application: ELISA  FCM  
    11524-R007-50
    11524-R007-100
    50 µg 
    100 µg 
    Add to Cart
    • Slide 1
    Reactivity: Human  
    Application: 
    11524-MM04-50
    11524-MM04-200
    11524-MM04-100
    11524-MM04-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
      Reactivity: Human  
      Application: FCM  
      11524-R007-F-25
      11524-R007-F-100
      25 Test 
      100 Tests 
      Add to Cart
      • Slide 1
      Reactivity: Human  
      Application: ELISA  
      11524-RP02-50
      11524-RP02-200
      11524-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
        Reactivity: Human  
        Application: ELISA  
        11524-RP01-400
        11524-RP01-200
        11524-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart

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          CD28/TP44 Related Area

          CD28/TP44 Related Pathways

            CD28/TP44 Summary & Protein Information

            CD28/TP44 Background

            Gene Summary: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
            General information above from NCBI
            Subunit structure: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2. {ECO:0000269|PubMed:15696168, ECO:0000269|PubMed:24098653}.
            Subcellular location: Membrane; Single-pass type I membrane protein.
            Tissue specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells.
            Sequence similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
            General information above from UniProt

            CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

            Immune Checkpoint
            Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
            Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

            Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            CD28/TP44 Alternative Name

            Tp44, [homo-sapiens]
            CD28,MGC138290,Tp44, [human]
            Cd28,CH29-189K17.3, [mouse]

            CD28/TP44 Related Studies

          • Keir ME, et al. (2005) The B7/CD28 costimulatory family in autoimmunity. Immunol Rev. 204: 128-43.
          • Sansom DM, et al. (2006) The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology. Immunol Rev. 212: 131-48.
          • Bjrgo E, et al. (2010) Novel mechanism of signaling by CD28. Immunol Lett. 129(1): 1-6.
          • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"