Hemagglutinin / HA: Hemagglutinin / HA Protein | Hemagglutinin / HA Antibody

Hemagglutinin / HA Background

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.

Reference for Hemagglutinin / HA

  • White JM, Hoffman LR, Arevalo JH, et al. (1997). ""Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin"". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.

Hemagglutinin / HA Antibody

There are 166 Hemagglutinin / HA antibodies which are validated in multiple tissues with various applications, including WB, ELISA, IHC-P, FCM, ICC/IF, IP, B/N, ELISA(Cap), ELISA(Det), HemagglutininInhibition(HI), Microneutralizaiton(MN). There are 105 Hemagglutinin / HA antibody for WB, 141 Hemagglutinin / HA antibody for ELISA, 113 Hemagglutinin / HA antibody for IHC-P, 114 Hemagglutinin / HA antibody for FCM, 123 Hemagglutinin / HA antibody for ICC/IF, 129 Hemagglutinin / HA antibody for IP, 2 Hemagglutinin / HA antibody for B/N, 9 Hemagglutinin / HA antibody for ELISA(Cap), 5 Hemagglutinin / HA antibody for ELISA(Det), 5 Hemagglutinin / HA antibody for HemagglutininInhibition(HI), 3 Hemagglutinin / HA antibody for Microneutralizaiton(MN). Among all these Hemagglutinin / HA antibodies, there are 44 anti-Hemagglutinin / HA mouse monoclonal antibodies , 20 anti-Hemagglutinin / HA rabbit monoclonal antibodies , 101 anti-Hemagglutinin / HA rabbit polyclonal antibodies , 1 anti-Hemagglutinin / HA . All the Hemagglutinin / HA anbodies are produced in house and all are in stock. Hemagglutinin / HA antibody customerized service is available.