Growth factors and their receptors play important roles in the regulation of cell division, development and differentiation. Growth factor receptors include wnt receptor, tie, neurotrophin receptor, ephrin receptor, insulin-like growth factor receptor (IGF receptor), epidermal growth factor receptor (EGF receptor), fibroblast growth factor receptor (FGF receptor), platelet-derived growth factor receptor (PDGF receptor) and vascular endothelial growth factor receptor (VEGF receptor), etc.
Growth factor receptors are transmembrane proteins which bind to specific growth factors and transmit the instructions conveyed by the factors to intracellular space. The growth factor receptors on cell surface are very common, and cells mainly contains receptors for several growth factors. Most growth factor receptors have a cysteine-rich region, which participate in signal transduction by receptor tyrosine kinase, e.g., the receptors for fibroblast growth factor ( FGF), vascular endothelial growth factor(VEGF), epidermal growth factor (EGF), insulin-like growth factor (IGF), and platelet-derived growth factor (PDGF), etc. Meanwhile, there are some receptors which mediate the signal transduction via receptor serine-threonine kinase, such as the receptor for transforming growth factor β.
* Being developed. Tell us your requirement so that the products of interest be placed on the priority list.
|TrkB/NTRK2||TrkC/NTRK3||EphA1/Eph Receptor A1|
|EphA2/Eph Receptor A2||EPHA3/Eph Receptor A3||EphA4/Eph Receptor A4|
|EphA6 / EHK2 / Eph Receptor A6||EphA7/Eph Receptor A7||EphB1/Eph Receptor B1|
|EphB2/Eph Receptor B2||EphB3/HEK2/Eph Receptor B3||EphB4/Eph Receptor B4|
|EphB6/Eph Receptor B6||IGF1R/CD221/IGF-I R||IGFLR1 / TMEM149|