All gp130 reagents are produced in house and quality controlled, including 21 gp130 Antibody, 2 gp130 ELISA, 52 gp130 Gene, 10 gp130 Lysate, 10 gp130 Protein, 3 gp130 qPCR. All gp130 reagents are ready to use.
Recombinant gp130 proteins are expressed by HEK293 Cells, CHO Cells with fusion tags as C-mouse IgG1-Fc & His, C-His, C-human IgG1-Fc, C-human IgG1-Fc & His, C-cleavage.
gp130antibodies are validated with different applications, which are ELISA, FCM, IHC-P, ICC/IF, IF, ELISA(Cap), WB, ELISA(Det).
gp130cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each gp130 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
gp130ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.