gp130 Protein & Antibody (CD130, IL6ST Protein)

glycoprotein 130 (Cluster of Differentiation 130, Interleukin 6 Signal Transducer)

gp130 Products

gp130 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
gp130/CD130	Human	gp130/CD130/Fc Protein, Recombinant	10974-H03H
gp130/CD130	Mouse	gp130/CD130 Protein, Recombinant	50135-M03C
gp130/CD130	Mouse	gp130/CD130 Protein, Recombinant	50135-M08H
gp130/CD130	Rat	gp130/CD130 Protein, Recombinant	80030-R06H
gp130/CD130	Rat	gp130/CD130 Protein, Recombinant	80030-R08H
gp130/CD130	Mouse	IL6ST / gp130 / CD130 Protein, Recombinant	50135-M03H

  10974-H03H: Measured by its ability to bind human IL11Ra in a functional Elisa.

  50135-M08H: Measured by its ability to bind mouse IL11Ra in a functional Elisa.

  50135-M03H: Measured by its ability to bind mouse IL11Ra in a functional Elisa.

gp130 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse gp130/CD130	WB, ELISA	gp130 / CD130 / IL6ST Antibody	50135-RP01
Mouse gp130/CD130	WB, ELISA	gp130 / CD130 / IL6ST Antibody (Antigen Affinity Purified)	50135-RP02
Rat gp130/CD130	WB, ELISA	gp130 / CD130 / IL6ST Antibody	80030-MM04
Rat gp130/CD130	WB, ELISA	gp130 / CD130 / IL6ST Antibody	80030-MM08

gp130 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
gp130/CD130	Mouse	Mus musculus gp130/CD130/IL6ST cDNA Clone	MG50135-M
gp130/CD130	Rat	Rattus norvegicus gp130/CD130/IL6ST cDNA Clone	RG80030-M

gp130 Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>gp130/IL6ST/CD130

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family & Receptor>>gp130/IL6ST/CD130

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-12 Family & Receptor>>gp130/IL6ST/CD130

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>gp130/CD130

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>gp130/CD130

gp130 Alternative Names

gp130, CD130, IL6ST, CDw130, GP130-RAPS, IL6R-beta [Homo sapiens]

gp130, CD130, Il6st, 5133400A03Rik, AA389424, BB405851 [Mus musculus]

Ac1055, Gp130, Il-6rb [Rattus norvegicus]

gp130 Background

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

gp130 Related Studies

1. Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
2. Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
3. Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.