Anti-gp130 Antibody

Cat: 80030-R108
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Anti-gp130 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-gp130 Antibody
Validated applications
ELISA,FCM
Species reactivity
Reacts with: Rat
Specificity
Rat gp130
Immunogen
Recombinant Rat gp130 / CD130 / IL6ST protein (Catalog#80030-R08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Rat gp130 / CD130 / IL6ST (rR gp130 / CD130 / IL6ST; Catalog#80030-R08H; NP_001008725.2; Met4-Glu618).
Source
Monoclonal Rabbit IgG Clone #108
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-gp130 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
FCM 1:25-1:100  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-gp130 Antibody (Rabbit Monoclonal antibody) Images
Rat IL6ST/gp130/CD130 Flow Cytometry (FC) 18777
Flow cytometric analysis of Rat IL6ST(CD130) expression on SD rat splenocytes. Cells were stained with purified anti-Rat IL6ST(CD130), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
gp130 Background Information

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

Full Name
interleukin 6 signal transducer
References
  • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-gp130 Antibody Rabbit Monoclonal ELISA(Cap) 50135-R001
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    Anti-gp130 Antibody (PE) Rabbit Monoclonal FCM 50135-R022-P
    Anti-gp130 Antibody Rabbit Monoclonal IHC-P 50135-R223
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    Anti-gp130 Antibody Mouse Monoclonal ELISA 10974-MM06
    Anti-gp130 Antibody Mouse Monoclonal FCM 10974-MM11
    Anti-gp130 Antibody (PE) Mouse Monoclonal FCM 10974-MM11-P
    Anti-gp130 Antibody Rabbit Polyclonal IHC-P,ICC/IF,IF 101867-T10
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