**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|Anti-gp130 Antibody (PE)||Rabbit||Monoclonal||FCM||80030-R108-P|
|Anti-gp130 Antibody (APC)||Rabbit||Monoclonal||FCM||50135-R022-A|
|Anti-gp130 Antibody (PE)||Rabbit||Monoclonal||FCM||50135-R022-P|
|Anti-gp130 Antibody (PE)||Mouse||Monoclonal||FCM||10974-MM11-P|