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IL6ST/gp130/CD130  ELISA Kit

All IL6ST Reagents

IL6ST/gp130/CD130

IL6ST/gp130/CD130 ELISA Kit

IL6ST/gp130/CD130 Related Area

IL6ST/gp130/CD130 Related Pathways



IL6ST/gp130/CD130 Related Protein, Antibody, cDNA Gene, and ELISA Kits

IL6ST/gp130/CD130 Related Protein, Antibody, cDNA Gene, and ELISA Kits

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IL6ST/gp130/CD130 Summary & Protein Information

IL6ST/gp130/CD130 Related Information

IL6ST/gp130/CD130 Background

Gene Summary: The protein encoded by IL6ST gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that IL6ST gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010]
General information above from NCBI
Subunit structure: Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK. {ECO:0000250, ECO:0000269|PubMed:11238858, ECO:0000269|PubMed:11251120, ECO:0000269|PubMed:12829785, ECO:0000269|PubMed:14527405, ECO:0000269|PubMed:8999038, ECO:0000269|PubMed:9406996}.
Domain: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; The box 1 motif is required for JAK interaction and/or activation.
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
Tissue specificity: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.
Induction: LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor. {ECO:0000269|PubMed:8999038}.
Post-translational: Phosphorylation of Ser-782 down-regulates cell surface expression. {ECO:0000269|PubMed:10811661}.; Heavily N-glycosylated. {ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:11251120, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218}.
Sequence similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. {ECO:0000305}.; Contains 5 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 Ig-like C2-type (immunoglobulin-like) domain. {ECO:0000305}.
General information above from UniProt

Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

IL6ST/gp130/CD130 Alternative Name

IL-6RB,D13Ertd699e, []
CD130,GP130,CDW130,IL-6RB, [homo-sapiens]
CD130,CDw130,gp130,GP130-RAPS,IL6R-beta,IL6ST, [human]
5133400A03Rik,AA389424,BB405851,CD130,gp130,Il6st, [mouse]
CD130,gp130,AA389424,BB405851,D13Ertd699e,5133400A03Rik, [mus-musculus]

IL6ST/gp130/CD130 Related Studies

  • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
  • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
  • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.
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