Frizzled 10 Protein

Frizzled 10 Protein Overview

Frizzled 10 reagents

By PCR with degenerate primers based on FZD transmembrane domain sequences, followed by screening a fetal lung cDNA library, Koike et al. (1999) obtained a cDNA encoding FZD10. The deduced 581-amino acid protein, which is 66% identical to FZD9 (601766), contains an N-terminal CRD; 7 transmembrane domains with 2 cys residues in the second and third extracellular loops; 2 N-linked glycosylation sites; and a C-terminal ser/thr-Xxx-val motif, which is a binding site for scaffold proteins with multiple PDZ domains. Northern blot analysis revealed wide expression of a 4.0-kb FZD10 transcript, with highest levels in placenta and fetal kidney, followed by fetal lung and brain. Within adult brain, expression was relatively high in cerebellum, followed by cerebral cortex, medulla, and spinal cord.

Frizzled 10 protein family

Belongs to the G-protein coupled receptor Fz/Smo family.

Frizzled 10 protein name

Recommended name
Frizzled-10
Short name
Fz-10||hFz10
Aliases
CD350
Alternative name
FzE7 CD_antigen: CD350

Frizzled 10 Protein Sequence

Species Human Frizzled 10 protein
Length 581
Mass (Da) 65336
Sequence Human Frizzled 10 protein sequence
Species Mouse Frizzled 10 protein
Length 582
Mass (Da) 65318
Sequence Mouse Frizzled 10 protein sequence
Species
Length
Mass (Da)
Sequence

Frizzled 10 Protein Molecular Weight & PI

Frizzled-10 precursor (Fz-10) (hFz10) (FzE7) (CD350 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 21-581 Frizzled-10.

Molecular weight (Da)

63139.97

Theoretical pI

8.75

Frizzled 10 Protein Interaction

Recombinant Frizzled 10 Protein Feature

Frizzled 10 Protein, Human, Recombinant (Fc Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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