One of the greatest benefits of monoclonal antibodies is specificity. However, some pitfalls in the use of monoclonal antibodies should be noted. All too often, monoclonal antibodies are characterized using fresh or frozen tissue. If the antibody is to be used for formalin-fixed specimens, the targeted epitope must survive fixation. In some cases, polyclonal antibodies that target multiple epitopes within a single antigen have a better chance of detecting that antigen than monoclonal antibodies that are restricted to a single epitope.