ENSA (Protein | Antibody | cDNA Clone | ELISA Kit)

All ENSA reagents are produced in house and quality controlled, including 1 ENSA Antibody, 32 ENSA Gene, 1 ENSA IP Kit, 2 ENSA Protein, 1 ENSA qPCR. All ENSA reagents are ready to use.

ENSA Protein (2)

    ENSA Antibody (1)

      ENSA cDNA Clone (32)


      In cloning vector

      In lentiviral vector

      ENSA qPCR Primer (1)

      ENSA Related Research Area

      ENSA Background

      Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. As a protein phosphatase inhibitor, ENSA specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Endosulfine alpha also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

      ENSA References

      • Ye M. et al., 2001, Genome Res. 10 (10): 1546-60.
      • Apiou F. et al., 1999, Diabetes 48 (9): 1873-6.
      • Lennon G. et al., 1997, Genome Res. 6 (9): 791-806.

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