ENSA (Protein | Antibody | cDNA Clone | ELISA Kit)

All ENSA reagents are produced in house and quality controlled, including 1 ENSA Antibody, 32 ENSA Gene, 1 ENSA IP Kit, 2 ENSA Protein, 1 ENSA qPCR. All ENSA reagents are ready to use.

ENSA Protein (2)

    ENSA Antibody (1)

      ENSA cDNA Clone (32)

      NM_021842.3

      In cloning vector

      In lentiviral vector

      ENSA qPCR Primer (1)

      ENSA Related Research Area

      ENSA Background

      Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. As a protein phosphatase inhibitor, ENSA specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Endosulfine alpha also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.

      ENSA References

      • Ye M. et al., 2001, Genome Res. 10 (10): 1546-60.
      • Apiou F. et al., 1999, Diabetes 48 (9): 1873-6.
      • Lennon G. et al., 1997, Genome Res. 6 (9): 791-806.

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