Ebola virus Glycoprotein (Protein|Antibody|cDNA Clone|ELISA Kit)

All Ebola virus Glycoprotein reagents are produced in house and quality controlled, including 17 Ebola virus Glycoprotein Antibody, 62 Ebola virus Glycoprotein Gene, 8 Ebola virus Glycoprotein IPKit, 24 Ebola virus Glycoprotein Lysate, 24 Ebola virus Glycoprotein Protein. All Ebola virus Glycoprotein reagents are ready to use.

Recombinant Ebola virus Glycoprotein proteins are expressed by Baculovirus-Insect Cells, HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc, C-cleavage, N-mouse IgG1-Fc.

Ebola virus Glycoprotein antibodies are validated with different applications, which are WB, IHC-P, IP, FCM, ICC/IF, IF, ELISA.

Ebola virus Glycoprotein cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Ebola virus Glycoprotein of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

Ebola virus Glycoprotein Protein (24)

Species

Ebola virus EBOV (subtype Sudan, strain Gulu) GP1 / Glycoprotein Protein (His Tag)

40094-V08B2

Expression host: Baculovirus-Insect Cells

EBOV EBOV-G/Ebola Glycoprotein Protein 11059
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Ebola virus Glycoprotein Antibody (17)

Application Clonality
Host

EBOV-G / Ebola Glycoprotein Antibody, Mouse MAb

40368-MM07

Application: WB,ELISA,IHC-P,FCM,ICC/IF,IF,IP

Clonality: MAb

EBOV EBOV-G/Ebola Glycoprotein Western blot (WB) 15134

Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) Glycoprotein / GP Antibody, Mouse MAb

40304-MM06

Application: ELISA,IHC-P,FCM,ICC/IF,IF,IP

Clonality: MAb

Ebola virus EBOV (subtype Zaire, strain Mayinga 1976) GP-RBD / Glycoprotein Antibody, Rabbit PAb

40304-RP01

Application: ELISA,IHC-P,FCM,ICC/IF,IF,IP

Clonality: PAb

Ebola virus EBOV (Subtype Sudan, strain Gulu) Glycoprotein / GP1 (mucin domain deleted) Antibody, Rabbit MAb

40094-R106

Application: WB,ELISA,IHC-P,FCM,ICC/IF,IF,IP

Clonality: MAb

EBOV EBOV-G/Ebola Glycoprotein Western blot (WB) 18433
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Ebola virus Glycoprotein cDNA Clone (62)

EBOV
Subtype Zaire, strain Mayinga 1976
subtype Reston, strain Pennsylvania or Reston
subtype Tai Forest, strain Cote d'Ivoire-94
Subtype Bundibugyo, strain Uganda 2007
Subtype Sudan, strain Gulu
subtype Zaire, strain H.sapiens-wt/GIN/2014/K

Ebola virus Glycoprotein IP Kit (8)

Ebola virus Glycoprotein Lysate (24)

The fourth gene of the EBOV genome encodes a 16-kDa envelope-attached glycoprotein (GP) and a 11 kDa secreted glycoprotein (sGP). Both GP and sGP have an identical 295-residue N-terminus, however, they have different C-terminal sequences. Recently, great attention has been paid to GP for vaccines design and entry inhibitors isolation. GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . The GP1 subunit contains a mucin domain and a receptor-binding domain (RBD); the GP2 subunit has a fusion peptide, a helical heptad-repeat (HR) region, a transmembrane (TM) domain, and a 4-residue cytoplasmic tail. The RBD of GP1 mediates the interaction of EBOV with cellular receptor (e.g. DC-SIGN/LSIGN, TIM-1, hMGL, NPC1, β-integrins, folate receptor-α, and Tyro3 family receptors), of which TIM1 and NPC1 are essential for EBOV entry; the mucin domain having N- and O-linked glycans enhances the viral attachment to cellular hMGL, and participates in shielding key neutralization epitopes, which helps the virus evades immune elimination. There are large conformation changes of GP2 during membrane fusion, which enhance the insertion of fusion loop into cellular membrane and facilitate the release of viral nucleocapsid core to cytoplasm.
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