Cytokines & Growth Factors

Cytokines & Growth Factors (interleukins, chemokines, interferons, tumor necrosis factors, colony stimulating factors and so on ) are a net-work of of tissue-specific regulators, controlling cell production, location, differentiation and movement. And they functions through receptors of cells around them. This makes cytokines and the corresponding receptors become the major drug targets for diseases, especially cancer, autoimmune disease and and allergic disease. Here we list the main drug targets included in cytokines and growth factors. And you also have access to elite reagents of these targets to facilitate your research.

Quick Guide:

Cytokines & Growth Factors Featured Sections

 
Cytokine (growth factor) drug targets related reagents and information.

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Cytokines regulate proliferation, differentiation, or other properties of stem cells.
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Interleulin family containing 38 ILs and the corresponding receptors
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Detailed information of chemokine family and the related reagents.

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Reagents and information related with TNF superfamily.

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Reagents and information related with interferon family.

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Cytokines & Growth Factors Families

Cytokines & Growth Factors Related Pathways

TGF-beta Signaling Pathway

  • • TGF-beta signaling is involved in the regulation of proliferation, differentiation and survival/or apoptosis of many cells, including glioma cells.
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  • • TGF-beta superfamily of cytokines bind to receptors at the cell surface, and recruit two type I receptors and two type II receptors forming a tetrameric complex.
TGF-beta   VEGF   TNF   EGFR   Canonical wnt   Death receptor   Notch

Cytokines & Growth Factors Reference

• Burgess A W. Growth factors and cytokines[J]. Reviews in Cell Biology and Molecular Medicine, 2015.
• Akdis M, et al. Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases[J]. Journal of allergy and clinical immunology, 2011, 127(3): 701-721. e70.
• Comerford I, McColl S R. Mini-review series: focus on chemokines[J]. Immunology and cell biology, 2011, 89(2): 183.