CSK cDNA Clone: Expression and Clone Vector / Plasmid
CSK cDNA / Gene Overview
CSK gene / cDNA is a protein-coding gene which located on 15q24.1. The CSK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, and frog.214 organisms have orthologs with human gene CSK.
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
CSK cDNA / Gene Sequence
LOCUS NM_004383 2755 bp mRNA linear PRI 24-JUN-2018
Homo sapiens C-terminal Src kinase (CSK), transcript variant 1, mRNA.
This sequence information is just for reference only.
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