CSK cDNA Clone: Expression and Clone Vector / Plasmid

CSK cDNA / Gene Overview

CSK gene / cDNA is a protein-coding gene which located on 15q24.1. The CSK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, C.elegans, and frog.214 organisms have orthologs with human gene CSK.

CSK cDNA / Gene Function

The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

CSK cDNA / Gene Sequence

LOCUS
LOCUS NM_004383 2755 bp mRNA linear PRI 24-JUN-2018
DEFINITION
Homo sapiens C-terminal Src kinase (CSK), transcript variant 1, mRNA.
ACCESSION
NM_004383
VERSION
NM_004383.2

This sequence information is just for reference only.

CSK Family & Reagents

CSK Gene family reagents (SH2 domain containing)

Approved Symbol Reagent list
ABL1
BLNK
CHN1
ITK
LYN
PTPN11
SH2D1A
SRC
STAT4
YES1
Approved Symbol Reagent list
BLK
BTK
FES
Lck
PTK6
PTPN6
SOCS3
STAT1
STAT6
   

CSK cDNA / Gene Expression

Broad expression in lymph node (RPKM 63.0), spleen (RPKM 47.7) and 24 other tissues