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Human CRABP1 Gene cDNA clone plasmid

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Human CRABP1 cDNA Clone Product Information
Gene_bank_ref_id:BC022069
RefSeq ORF Size:414bp
cDNA Description:Full length Clone DNA of Homo sapiens cellular retinoic acid binding protein 1.
Gene Synonym:RBP5, CRABP, CRABPI, CRABP-I
Species:Human
Vector:pGEM-T Vector
Plasmid:pGEM-CRABP1
Restriction Site:
Tag Sequence:
Sequence Description:Identical with the Gene Bank Ref. ID sequence.
Sequencing primers:
Promoter:
Application:
Antibiotic in E.coli:
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at room temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
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Background

CRABP1 is a specific binding protein for a vitamin A family member. It is thought that CRABP1 plays an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. It forms a beta-barrel structure which accommodates hydrophobic ligands in its interior.

References
  • Wu Q. et al., 2007, Mol Cancer. 6: 45.
  • Tanaka K. et al., 2007, Oncogene. 26 (44): 6456-68.
  • Lind GE. et al., 2007, Cell Oncol. 28 (5-6): 259-72.
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    Catalog: HG14511-G
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