|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human IL23R ORF mammalian expression plasmid, C-GFPSpark tag||HG13840-ACG|
|Human IL23R ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13840-ACR|
|Human IL23R ORF mammalian expression plasmid, C-Flag tag||HG13840-CF|
|Human IL23R ORF mammalian expression plasmid, C-His tag||HG13840-CH|
|Human IL23R ORF mammalian expression plasmid, C-Myc tag||HG13840-CM|
|Human IL23R ORF mammalian expression plasmid, C-HA tag||HG13840-CY|
|Human IL23R Gene cDNA clone plasmid||HG13840-G|
|Human IL23R ORF mammalian expression plasmid, N-Flag tag||HG13840-NF|
|Human IL23R ORF mammalian expression plasmid, N-His tag||HG13840-NH|
|Human IL23R ORF mammalian expression plasmid, N-Myc tag||HG13840-NM|
|Human IL23R ORF mammalian expression plasmid, N-HA tag||HG13840-NY|
|Human IL23R natural ORF mammalian expression plasmid||HG13840-UT|
|Learn more about expression Vectors|
IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.