|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human SOCS3 ORF mammalian expression plasmid, C-GFPSpark tag||HG11315-ACG|
|Human SOCS3 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11315-ACR|
|Human SOCS3 ORF mammalian expression plasmid, N-GFPSpark tag||HG11315-ANG|
|Human SOCS3 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Flag-tagged||HG11315-CF|
|Human SOCS3 ORF mammalian expression plasmid, C-His tag||HG11315-CH|
|Human SOCS3 ORF mammalian expression plasmid, C-Myc tag||HG11315-CM|
|Human SOCS3 ORF mammalian expression plasmid, C-HA tag||HG11315-CY|
|Human SOCS3 ORF mammalian expression plasmid, N-Flag tag||HG11315-NF|
|Human SOCS3 ORF mammalian expression plasmid, N-His tag||HG11315-NH|
|Human SOCS3 ORF mammalian expression plasmid, N-Myc tag||HG11315-NM|
|Human SOCS3 ORF mammalian expression plasmid, N-HA tag||HG11315-NY|
|Human SOCS3 natural ORF mammalian expression plasmid||HG11315-UT|
|Learn more about expression Vectors|
Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 / CIS3 is involved in negative regulation of cytokines that signal through the JAK / STAT pathway. SOCS3 / CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3 / CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3 / CIS3 regulates IL-6 signaling. SOCS3 / CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3 / CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.