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Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged

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LAMP1cDNA Clone Product Information
Gene_bank_ref_id:NM_005561.3
cDNA Size:1254
cDNA Description:ORF Clone of Homo sapiens lysosomal-associated membrane protein 1 DNA.
Gene Synonym:LAMPA, CD107a, LGP120, LAMP1
Species:Human
Vector:pCMV/hygro
Restriction Site:KpnI + XhoI
Tag Sequence:
Sequence Description:Identical with the Gene Bank Ref. ID sequence except for two point mutation: 6 G/T and 556 C/A not causing the amino acid variation.
Shipping_carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pCMV/hygro Vector Information
 
Vector Name pCMV/hygro
Vector Size 5657bp
Vector Type Mammalian Expression Vector
Expression Method Constiutive ,Stable / Transient
Promoter CMV
Antibiotic Resistance Ampicillin
Selection In Mammalian Cells Hygromycin
Protein Tag None
Sequencing Primer Forward:T7(TAATACGACTCACTATAGGG)
Reverse:BGH(TAGAAGGCACAGTCGAGG)


Schematic of pCMV/hygro Multiple Cloning Sites
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged on other vectors
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHG11215-ACG$325
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tagHG11215-ACR$325
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHG11215-CF$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedHG11215-CH$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedHG11215-CM$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHG11215-CY$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone)HG11215-M$95
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedHG11215-M-F$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedHG11215-NF$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedHG11215-NH$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedHG11215-NM$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedHG11215-NY$295
Human LAMP-1 / CD107a / LAMP1 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG11215-UT$295
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Background

Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2% of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.

References
  • Parkinson-Lawrence EJ, et al. (2005) Immunochemical analysis of CD107a (LAMP-1). Cell Immunol. 236(1-2): 161-6.
  • Barrachina M, et al. (2006) Lysosome-associated membrane protein 1 (LAMP-1) in Alzheimer's disease. Neuropathol Appl Neurobiol. 32(5): 505-16.
  • Zhang H, et al. (2010) Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol. 55(6): 417-25.
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