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Human PRDX1 Gene cDNA Clone (full-length ORF Clone)

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PRDX1cDNA Clone Product Information
Gene_bank_ref_id:BC007063.1
cDNA Size:600
cDNA Description:ORF Clone of Homo sapiens peroxiredoxin 1 DNA.
Gene Synonym:PAG, PAGA, PAGB, PRX1, PRXI, MSP23, NKEFA, TDPX2, PRDX1
Species:Human
Vector:pMD18-T Simple Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with the Gene Bank Ref. ID sequence.
Shipping_carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pMD18-T Simple Vector Information

pMD18-T Simple Vector is a high-efficiency TA cloning vector constructed from pUC18, of which the initial multiple cloning sites (MCS) were destroyed. Thus the cDNA should be amplified by PCR with primers containing a restriction site for subclone. Competent cells appropriate for pUC18 are also appropriated for the Vector, e.g. JM109, DH5α, TOP10. The pMD18-T Simple Vector is 2.6kb in size. Selection of the plasmid in E. coli is conferred by the ampicillin resistance gene. The coding sequence was inserted by TA cloning at site 425.

pMD18-T Simple Usage Suggestion

The coding sequence can be amplified by PCR with M13-47 and RV-M primers.

Vector Sequence Download
Human PRDX1 Gene cDNA Clone (full-length ORF Clone) on other vectors
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHG11194-ACG$325
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tagHG11194-ACR$325
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-GFPSpark-taggedHG11194-ANG$325
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-OFPSpark tagHG11194-ANR$325
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHG11194-CF$295
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedHG11194-CH$295
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedHG11194-CM$295
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHG11194-CY$295
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-taggedHG11194-M-F$395
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG11194-M-N$395
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedHG11194-NF$295
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedHG11194-NH$295
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedHG11194-NM$295
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedHG11194-NY$295
Human PRDX1 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG11194-UT$295
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Background

Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.

References
  • Neumann, CA. et al., 2003, Nature 424 (6948): 561-5
  • Gisin, J. et al., 2005, J Clin Pathol. 58 (11): 1229-31.
  • Hoshino, I. et al., 2007, Oncol Rep. 18 (4): 867-71.
  • Cao, J. et al., 2009, EMBO J. 28 (10): 1505-17.
  • Size / Price
    Catalog:HG11194-M
    List Price: $195.00  (Save $100.00)
    Price:$95.00      [How to order]
    Availability5 business days
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