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Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone)

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OXSR1/OSR1cDNA Clone Product Information
Gene_bank_ref_id:NM_005109.2
cDNA Size:1584
cDNA Description:ORF Clone of Homo sapiens oxidative-stress responsive 1 DNA.
Gene Synonym:OSR1, KIAA1101, OXSR1
Species:Human
Vector:pMD18-T Simple Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with the Gene Bank Ref. ID sequence.
Shipping_carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pMD18-T Simple Vector Information

pMD18-T Simple Vector is a high-efficiency TA cloning vector constructed from pUC18, of which the initial multiple cloning sites (MCS) were destroyed. Thus the cDNA should be amplified by PCR with primers containing a restriction site for subclone. Competent cells appropriate for pUC18 are also appropriated for the Vector, e.g. JM109, DH5α, TOP10. The pMD18-T Simple Vector is 2.6kb in size. Selection of the plasmid in E. coli is conferred by the ampicillin resistance gene. The coding sequence was inserted by TA cloning at site 425.

pMD18-T Simple Usage Suggestion

The coding sequence can be amplified by PCR with M13-47 and RV-M primers.

Vector Sequence Download
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone) on other vectors
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHG10727-ACG$345
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tagHG10727-ACR$345
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-GFPSpark-taggedHG10727-ANG$345
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-OFPSpark tagHG10727-ANR$345
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHG10727-CF$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedHG10727-CH$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedHG10727-CM$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHG10727-CY$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-taggedHG10727-M-F$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone) expression ready, untaggedHG10727-M-N$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedHG10727-NF$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedHG10727-NH$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedHG10727-NM$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedHG10727-NY$315
Human OXSR1 / OSR1 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG10727-UT$315
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Background

Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of potential regulators surveyed, endogenous OXSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl. OXSR1 did not increase the activity of coexpressed JNK, nor did it activate three other MAPKs, p38, ERK2, and ERK5. Phosphorylation by OXSR1 modulates the G protein sensitivity of PAK isoforms. The OXSR1 and SPAK are key enzymes in a signalling cascade regulating the activity of Na+/K+/2Cl- co-transporters (NKCCs) in response to osmotic stress. Both kinases have a conserved carboxy-terminal (CCT) domain, which recognizes a unique peptide (Arg-Phe-Xaa-Val) motif. The OXSR1 and SPAK kinases specifically recognize their upstream activators and downstream substrates.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"