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Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone)

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CAMK2AcDNA Clone Product Information
Gene_bank_ref_id:NM_171825.1
cDNA Size:1437
cDNA Description:ORF Clone of Homo sapiens calcium/calmodulin-dependent protein kinase II alpha DNA.
Gene Synonym:CAMKA, KIAA0968
Species:Human
Vector:pMD18-T Simple Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with the Gene Bank Ref. ID sequence except for the point mutation 1377T/C not causing the amino acid variation.
Shipping_carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pMD18-T Simple Vector Information

pMD18-T Simple Vector is a high-efficiency TA cloning vector constructed from pUC18, of which the initial multiple cloning sites (MCS) were destroyed. Thus the cDNA should be amplified by PCR with primers containing a restriction site for subclone. Competent cells appropriate for pUC18 are also appropriated for the Vector, e.g. JM109, DH5α, TOP10. The pMD18-T Simple Vector is 2.6kb in size. Selection of the plasmid in E. coli is conferred by the ampicillin resistance gene. The coding sequence was inserted by TA cloning at site 425.

pMD18-T Simple Usage Suggestion

The coding sequence can be amplified by PCR with M13-47 and RV-M primers.

Vector Sequence Download
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone) on other vectors
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHG10648-ACG$325
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tagHG10648-ACR$325
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, N-GFPSpark-taggedHG10648-ANG$325
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, N-OFPSpark tagHG10648-ANR$325
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHG10648-CF$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedHG10648-CH$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedHG10648-CM$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHG10648-CY$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-taggedHG10648-M-F$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG10648-M-N$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedHG10648-NF$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedHG10648-NH$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedHG10648-NM$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedHG10648-NY$295
Human CaM Kinase 2A Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG10648-UT$295
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Background

Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII. It has been found to play a critical role in sustaining activation of CAMKII at the postsynaptic density. Studies have found that knockout mice without CAMKIIA demonstrate a low frequency of LTP. Additionally, these mice do not form persistent, stable place cells in the hippocampus.

References
  • Lin CR, et al. (1987). Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. Proc Natl Acad Sci U S A. 84 (16): 5962-6.
  • Walikonis RS, et al. (2001) Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin. J Neurosci. 21 (2): 423-33.
  • Gardoni F, et al. (2003) CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J Biol Chem. 278 (45): 44745-52.
  • Size / Price
    Catalog:HG10648-M
    List Price: $95.00  (Save $0.00)
    Price:$95.00      [How to order]
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