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Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone)

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CD89/FCARcDNA Clone Product Information
Gene_bank_ref_id:NM_002000.2
cDNA Size:864
cDNA Description:ORF Clone of Homo sapiens Fc fragment of IgA, receptor for (FCAR), transcript variant 1 DNA.
Gene Synonym:CD89, FCAR
Species:Human
Vector:pMD18-T Simple Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with the Gene Bank Ref. ID sequence.
Shipping_carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pMD18-T Simple Vector Information

pMD18-T Simple Vector is a high-efficiency TA cloning vector constructed from pUC18, of which the initial multiple cloning sites (MCS) were destroyed. Thus the cDNA should be amplified by PCR with primers containing a restriction site for subclone. Competent cells appropriate for pUC18 are also appropriated for the Vector, e.g. JM109, DH5α, TOP10. The pMD18-T Simple Vector is 2.6kb in size. Selection of the plasmid in E. coli is conferred by the ampicillin resistance gene. The coding sequence was inserted by TA cloning at site 425.

pMD18-T Simple Usage Suggestion

The coding sequence can be amplified by PCR with M13-47 and RV-M primers.

Vector Sequence Download
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone) on other vectors
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHG10414-ACG$325
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tagHG10414-ACR$325
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHG10414-CF$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedHG10414-CH$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedHG10414-CM$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHG10414-CY$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone) expression ready, FLAG-taggedHG10414-M-F$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone) expression ready, untaggedHG10414-M-N$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedHG10414-NF$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedHG10414-NH$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedHG10414-NM$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedHG10414-NY$295
Human CD89 / FCAR transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG10414-UT$295
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Background

FCAR, also called FcαRI or CD89, is a type I  transmembrane receptor for Fc region of IgA which is the most abundant immunoglobulin in mucosal areas but is only the second most common antibody isotype in serum. This receptor is present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, especially phagocytes located in mucosal areas. Upon ligand IgA binding, FcαRI associates with the FcR γ signaling molecule bearing the immunoreceptor tyrosine-based activation motif (ITAM) through a unique charge-based mechanism and triggers multiple cell-mediated immune responses. It has been reported that Fc RI is a dual-function receptor that can mediate both inflammatory and anti-inflammatory responses depending on the type of interaction with its ligand. Sustained aggregation of FCAR results in activation of target-cell functions such as antigen presentation and cytokine release. In contrast, Monomeric targeting with serum IgA or with a variety of anti-FcαRI Fab fragments triggers an inhibitory response and additionally induces apoptosis. FcαRI thus play an fundamental role in preventing tumor development and growth, as well as in controlling inflammation.

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Catalog:HG10414-M
List Price: $95.00  (Save $0.00)
Price:$95.00      [How to order]
Availability5 business days
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