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Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged

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ErbB4/HER4cDNA Clone Product Information
Gene_bank_ref_id:NM_001042599.1
cDNA Size:3879
cDNA Description:ORF Clone of Homo sapiens v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), transcript variant JM-a/CVT-2 DNA.
Gene Synonym:HER4, MGC138404, p180erbB4
Species:Human
Vector:pCMV/hygro-His
Restriction Site:XbaI
Tag Sequence:His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Sequence Description:Identical with the Gene Bank Ref. ID sequence.
Shipping_carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pCMV/hygro-HIs Vector Information
 
Vector Name pCMV/hygro-His
Vector Size 5687bp
Vector Type Mammalian Expression Vector
Expression Method Constiutive ,Stable / Transient
Promoter CMV
Antibiotic Resistance Ampicillin
Selection In Mammalian Cells Hygromycin
Protein Tag His
Sequencing Primer Forward:T7(TAATACGACTCACTATAGGG)
Reverse:BGH(TAGAAGGCACAGTCGAGG)

Schematic of pCMV/hygro-His Multiple Cloning Sites

His Tag Info

A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.

Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.

Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged on other vectors
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, C-GFPSpark-taggedHG10363-ACG$475
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tagHG10363-ACR$475
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, C-FLAG-taggedHG10363-CF$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, C-His-taggedHG10363-CH$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, C-Myc-taggedHG10363-CM$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, C-HA-taggedHG10363-CY$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone)HG10363-M$195
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG10363-M-N$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, N-FLAG-taggedHG10363-NF$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, N-His-taggedHG10363-NH$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, N-Myc-taggedHG10363-NM$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-taggedHG10363-NY$445
Human ErbB4 / HER4 transcript variant JM-a / CVT-2 Gene cDNA Clone (full-length ORF Clone), expression ready, untaggedHG10363-UT$445
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Background

ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. And lower levels in thymus, lung, salivary gland, and pancreas. It specifically binds to and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation, induction of milk proteins and lactation.

References
  • Huang, Y Z, et al. (2000) Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron. 26(2):443-55.
  • Garcia, R A, et al. (2000) The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc Natl Acad Sci. 97(7):3596-601.
  • Silberberg G, et al. (2006) The involvement of ErbB4 with schizophrenia: association and expression studies. Am J Med Genet. 141(B2):142-8.
  • Sardi SP, et al. (2006) Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell. 127(1):185-97.
  • Size / Price
    Catalog:HG10363-M-H
    List Price: $445.00  (Save $0.00)
    Price:$445.00      [How to order]
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