|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokaryotic expression systems.
|Human EGFR ORF mammalian expression plasmid, C-GFPSpark tag||HG10001-ACG|
|Human EGFR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10001-ACR|
|Human EGFR ORF mammalian expression plasmid, C-His tag||HG10001-CH|
|Human EGFR ORF mammalian expression plasmid, C-Myc tag||HG10001-CM|
|Human EGFR ORF mammalian expression plasmid, N-Flag tag||HG10001-NF|
|Human EGFR ORF mammalian expression plasmid, N-His tag||HG10001-NH|
|Human EGFR ORF mammalian expression plasmid, N-Myc tag||HG10001-NM|
|Human EGFR ORF mammalian expression plasmid, N-HA tag||HG10001-NY|
|Human EGFR natural ORF mammalian expression plasmid||HG10001-UT|
|Learn more about expression Vectors|
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.