|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A polyhistidine-tag is an amino acid motif in proteins that consists of at least five histidine (His) residues, often at the N- or C-terminus of the protein.
Polyhistidine-tags are often used for affinity purification of polyhistidine-tagged recombinant proteins expressed in Escherichia coli and other prokarfyotic expression systems.
|Mouse MBL ORF mammalian expression plasmid, C-GFPSpark tag||MG50063-ACG|
|Mouse MBL ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50063-ACR|
|Mouse MBL ORF mammalian expression plasmid, C-Flag tag||MG50063-CF|
|Mouse MBL ORF mammalian expression plasmid, C-His tag||MG50063-CH|
|Mouse MBL ORF mammalian expression plasmid, C-Myc tag||MG50063-CM|
|Mouse MBL ORF mammalian expression plasmid, C-HA tag||MG50063-CY|
|Mouse MBL Gene cDNA clone plasmid||MG50063-M|
|Mouse MBL ORF mammalian expression plasmid, N-Flag tag||MG50063-NF|
|Mouse MBL ORF mammalian expression plasmid, N-His tag||MG50063-NH|
|Mouse MBL ORF mammalian expression plasmid, N-Myc tag||MG50063-NM|
|Mouse MBL ORF mammalian expression plasmid, N-HA tag||MG50063-NY|
|Mouse MBL natural ORF mammalian expression plasmid||MG50063-UT|
|Learn more about expression Vectors|
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.