|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human TPP1 ORF mammalian expression plasmid, C-GFPSpark tag||HG13619-ACG|
|Human TPP1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13619-ACR|
|Human TPP1 ORF mammalian expression plasmid, C-Flag tag||HG13619-CF|
|Human TPP1 ORF mammalian expression plasmid, C-His tag||HG13619-CH|
|Human TPP1 ORF mammalian expression plasmid, C-Myc tag||HG13619-CM|
|Human TPP1 ORF mammalian expression plasmid, C-HA tag||HG13619-CY|
|Human TPP1 Gene cDNA clone plasmid||HG13619-G|
|Human TPP1 ORF mammalian expression plasmid, N-Flag tag||HG13619-NF|
|Human TPP1 ORF mammalian expression plasmid, N-His tag||HG13619-NH|
|Human TPP1 ORF mammalian expression plasmid, N-Myc tag||HG13619-NM|
|Human TPP1 ORF mammalian expression plasmid, N-HA tag||HG13619-NY|
|Human TPP1 natural ORF mammalian expression plasmid||HG13619-UT|
|Learn more about expression Vectors|
Tripeptidyl-peptidase 1 (TPP1 / CLN2) is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. TPP1 / CLN2 May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Defects in TPP1 / CLN2 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2), a form of neuronal ceroid lipofuscinosis which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.