|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human PROCR ORF mammalian expression plasmid, C-GFPSpark tag||HG13320-ACG|
|Human PROCR ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13320-ACR|
|Human PROCR ORF mammalian expression plasmid, C-Flag tag||HG13320-CF|
|Human PROCR ORF mammalian expression plasmid, C-His tag||HG13320-CH|
|Human PROCR ORF mammalian expression plasmid, C-Myc tag||HG13320-CM|
|Human PROCR ORF mammalian expression plasmid, C-HA tag||HG13320-CY|
|Human PROCR Gene cDNA clone plasmid||HG13320-G|
|Human PROCR ORF mammalian expression plasmid, N-Flag tag||HG13320-NF|
|Human PROCR ORF mammalian expression plasmid, N-His tag||HG13320-NH|
|Human PROCR ORF mammalian expression plasmid, N-Myc tag||HG13320-NM|
|Human PROCR ORF mammalian expression plasmid, N-HA tag||HG13320-NY|
|Human PROCR natural ORF mammalian expression plasmid||HG13320-UT|
|Learn more about expression Vectors|
Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case, protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa, turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR, activated protein C performs its cytoprotective effects, acting on the effector substrate PAR-1, protease-activated receptor-1. To a degree, APC's anticoagulant properties are independent of its cytoprotective ones, in that expression of one pathway is not affected by the existence of the other.