|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human FGF18 ORF mammalian expression plasmid, C-GFPSpark tag||HG13206-ACG|
|Human FGF18 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13206-ACR|
|Human FGF18 ORF mammalian expression plasmid, C-Flag tag||HG13206-CF|
|Human FGF18 ORF mammalian expression plasmid, C-His tag||HG13206-CH|
|Human FGF18 ORF mammalian expression plasmid, C-Myc tag||HG13206-CM|
|Human FGF18 ORF mammalian expression plasmid, C-HA tag||HG13206-CY|
|Human FGF18 Gene cDNA clone plasmid||HG13206-G|
|Human FGF18 ORF mammalian expression plasmid, N-Flag tag||HG13206-NF|
|Human FGF18 ORF mammalian expression plasmid, N-His tag||HG13206-NH|
|Human FGF18 ORF mammalian expression plasmid, N-Myc tag||HG13206-NM|
|Human FGF18 ORF mammalian expression plasmid, N-HA tag||HG13206-NY|
|Human FGF18 natural ORF mammalian expression plasmid||HG13206-UT|
|Learn more about expression Vectors|
Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that FGF18 is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Experiment datas identified FGF18 as a selective ligand for FGFR3 in limb bud mesenchymal cells, which suppressed proliferation and promoted their differentiation and production of cartilage matrix. FGF18 appears to regulate cell proliferation and differentiation positively in osteogenesis and negatively in chondrogenesis.