|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human PTS ORF mammalian expression plasmid, C-GFPSpark tag||HG14332-ACG|
|Human PTS ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG14332-ACR|
|Human PTS ORF mammalian expression plasmid, N-GFPSpark tag||HG14332-ANG|
|Human PTS ORF mammalian expression plasmid, N-OFPSpark / RFP tag||HG14332-ANR|
|Human PTS ORF mammalian expression plasmid, C-Flag tag||HG14332-CF|
|Human PTS ORF mammalian expression plasmid, C-His tag||HG14332-CH|
|Human PTS ORF mammalian expression plasmid, C-Myc tag||HG14332-CM|
|Human PTS ORF mammalian expression plasmid, C-HA tag||HG14332-CY|
|Human PTS Gene cDNA clone plasmid||HG14332-G|
|Human PTS ORF mammalian expression plasmid, N-Flag tag||HG14332-NF|
|Human PTS ORF mammalian expression plasmid, N-His tag||HG14332-NH|
|Human PTS ORF mammalian expression plasmid, N-Myc tag||HG14332-NM|
|Human PTS ORF mammalian expression plasmid, N-HA tag||HG14332-NY|
|Human PTS natural ORF mammalian expression plasmid||HG14332-UT|
|Learn more about expression Vectors|
PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. PTS is involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. PTS also catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A), also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.