|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Mouse AGER ORF mammalian expression plasmid, C-GFPSpark tag||MG50489-ACG|
|Mouse AGER ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50489-ACR|
|Mouse AGER ORF mammalian expression plasmid, C-Flag tag||MG50489-CF|
|Mouse AGER ORF mammalian expression plasmid, C-His tag||MG50489-CH|
|Mouse AGER ORF mammalian expression plasmid, C-Myc tag||MG50489-CM|
|Mouse AGER ORF mammalian expression plasmid, C-HA tag||MG50489-CY|
|Mouse AGER Gene cDNA clone plasmid||MG50489-M|
|Mouse AGER ORF mammalian expression plasmid, N-Flag tag||MG50489-NF|
|Mouse AGER ORF mammalian expression plasmid, N-His tag||MG50489-NH|
|Mouse AGER ORF mammalian expression plasmid, N-Myc tag||MG50489-NM|
|Mouse AGER ORF mammalian expression plasmid, N-HA tag||MG50489-NY|
|Mouse AGER natural ORF mammalian expression plasmid||MG50489-UT|
|Learn more about expression Vectors|
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.