|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human RSPO2 ORF mammalian expression plasmid, C-GFPSpark tag||HG13084-ACG|
|Human RSPO2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13084-ACR|
|Human RSPO2 ORF mammalian expression plasmid, C-Flag tag||HG13084-CF|
|Human RSPO2 ORF mammalian expression plasmid, C-His tag||HG13084-CH|
|Human RSPO2 ORF mammalian expression plasmid, C-Myc tag||HG13084-CM|
|Human RSPO2 ORF mammalian expression plasmid, C-HA tag||HG13084-CY|
|Human RSPO2 Gene cDNA clone plasmid||HG13084-G|
|Human RSPO2 ORF mammalian expression plasmid, N-Flag tag||HG13084-NF|
|Human RSPO2 ORF mammalian expression plasmid, N-His tag||HG13084-NH|
|Human RSPO2 ORF mammalian expression plasmid, N-Myc tag||HG13084-NM|
|Human RSPO2 ORF mammalian expression plasmid, N-HA tag||HG13084-NY|
|Human RSPO2 natural ORF mammalian expression plasmid||HG13084-UT|
|Learn more about expression Vectors|
R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors.