|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human NRG4 ORF mammalian expression plasmid, C-GFPSpark tag||HG12183-ACG|
|Human NRG4 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG12183-ACR|
|Human NRG4 ORF mammalian expression plasmid, C-Flag tag||HG12183-CF|
|Human NRG4 ORF mammalian expression plasmid, C-His tag||HG12183-CH|
|Human NRG4 ORF mammalian expression plasmid, C-Myc tag||HG12183-CM|
|Human NRG4 ORF mammalian expression plasmid, C-HA tag||HG12183-CY|
|Human NRG4 Gene cDNA clone plasmid||HG12183-G|
|Human NRG4 ORF mammalian expression plasmid, N-Flag tag||HG12183-NF|
|Human NRG4 ORF mammalian expression plasmid, N-His tag||HG12183-NH|
|Human NRG4 ORF mammalian expression plasmid, N-Myc tag||HG12183-NM|
|Human NRG4 ORF mammalian expression plasmid, N-HA tag||HG12183-NY|
|Human NRG4 natural ORF mammalian expression plasmid||HG12183-UT|
|Learn more about expression Vectors|
NRG4 (neuregulin 4) is a member of the neuregulin protein family. The neuregulins consist of four structurally-related proteins that are part of the EGF family of proteins. It has been shown that these proteins have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses. NRG4 contains 1 EGF-like domain. It activates type-1 growth factor receptors to initiating cell-to-cell signaling through tyrosine phosphorylation. NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. However, it does not bind to the ERBB1, ERBB2 and ERBB3 receptors.