|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Mouse SLAMF6 ORF mammalian expression plasmid, C-GFPSpark tag||MG50275-ACG|
|Mouse SLAMF6 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||MG50275-ACR|
|Mouse SLAMF6 ORF mammalian expression plasmid, C-Flag tag||MG50275-CF|
|Mouse SLAMF6 ORF mammalian expression plasmid, C-His tag||MG50275-CH|
|Mouse SLAMF6 ORF mammalian expression plasmid, C-Myc tag||MG50275-CM|
|Mouse SLAMF6 ORF mammalian expression plasmid, C-HA tag||MG50275-CY|
|Mouse SLAMF6 Gene cDNA clone plasmid||MG50275-M|
|Mouse SLAMF6 ORF mammalian expression plasmid, N-Flag tag||MG50275-NF|
|Mouse SLAMF6 ORF mammalian expression plasmid, N-His tag||MG50275-NH|
|Mouse SLAMF6 ORF mammalian expression plasmid, N-Myc tag||MG50275-NM|
|Mouse SLAMF6 ORF mammalian expression plasmid, N-HA tag||MG50275-NY|
|Mouse SLAMF6 natural ORF mammalian expression plasmid||MG50275-UT|
|Learn more about expression Vectors|
SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.