|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human IL12RB1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11674-ACG|
|Human IL12RB1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11674-ACR|
|Human IL12RB1 ORF mammalian expression plasmid, C-Flag tag||HG11674-CF|
|Human IL12RB1 ORF mammalian expression plasmid, C-His tag||HG11674-CH|
|Human IL12RB1 ORF mammalian expression plasmid, C-Myc tag||HG11674-CM|
|Human IL12RB1 ORF mammalian expression plasmid, C-HA tag||HG11674-CY|
|Human IL12RB1 Gene cDNA clone plasmid||HG11674-M|
|Human IL12RB1 natural ORF mammalian expression plasmid||HG11674-M-N|
|Human IL12RB1 ORF mammalian expression plasmid, N-Flag tag||HG11674-NF|
|Human IL12RB1 ORF mammalian expression plasmid, N-His tag||HG11674-NH|
|Human IL12RB1 ORF mammalian expression plasmid, N-Myc tag||HG11674-NM|
|Human IL12RB1 ORF mammalian expression plasmid, N-HA tag||HG11674-NY|
|Human IL12RB1 natural ORF mammalian expression plasmid||HG11674-UT|
|Learn more about expression Vectors|
Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of IL12RB1 and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. IL12RB1(CD212) Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. It associated with IL12RB2 it forms a functional, high affinity receptor for IL12. IL12RB1(CD212) associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.