|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human TREML2 ORF mammalian expression plasmid, C-GFPSpark tag||HG11655-ACG|
|Human TREML2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11655-ACR|
|Human TREML2 ORF mammalian expression plasmid, C-Flag tag||HG11655-CF|
|Human TREML2 ORF mammalian expression plasmid, C-His tag||HG11655-CH|
|Human TREML2 ORF mammalian expression plasmid, C-Myc tag||HG11655-CM|
|Human TREML2 ORF mammalian expression plasmid, C-HA tag||HG11655-CY|
|Human TREML2 Gene cDNA clone plasmid||HG11655-M|
|Human TREML2 ORF mammalian expression plasmid, N-Flag tag||HG11655-NF|
|Human TREML2 ORF mammalian expression plasmid, N-His tag||HG11655-NH|
|Human TREML2 ORF mammalian expression plasmid, N-Myc tag||HG11655-NM|
|Human TREML2 ORF mammalian expression plasmid, N-HA tag||HG11655-NY|
|Human TREML2 natural ORF mammalian expression plasmid||HG11655-UT|
|Learn more about expression Vectors|
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There maybe a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8(+) T cell activation.