|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human JAG1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11648-ACG|
|Human JAG1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11648-ACR|
|Human JAG1 ORF mammalian expression plasmid, C-Flag tag||HG11648-CF|
|Human JAG1 ORF mammalian expression plasmid, C-His tag||HG11648-CH|
|Human JAG1 ORF mammalian expression plasmid, C-Myc tag||HG11648-CM|
|Human JAG1 ORF mammalian expression plasmid, C-HA tag||HG11648-CY|
|Human JAG1 Gene cDNA clone plasmid||HG11648-M|
|Human JAG1 ORF mammalian expression plasmid, N-Flag tag||HG11648-NF|
|Human JAG1 ORF mammalian expression plasmid, N-His tag||HG11648-NH|
|Human JAG1 ORF mammalian expression plasmid, N-Myc tag||HG11648-NM|
|Human JAG1 ORF mammalian expression plasmid, N-HA tag||HG11648-NY|
|Human JAG1 natural ORF mammalian expression plasmid||HG11648-UT|
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Protein Jagged 1, also known as JAG1, JAGL1 and CD339, is a single-pass type I membrane protein which contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expression of JAG1/Jagged 1 is up-regulated in cervical squamous cell carcinoma. JAG1/Jagged 1 is also expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. JAG1/Jagged 1 is a ligand for multiple Notch receptors. It is involved in the mediation of Notch signaling. JAG1/Jagged 1 may be involved in cell-fate decisions during hematopoiesis.
JAG1/Jagged 1 seems to be involved in early and late stages of mammalian cardiovascular development. It inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1/Jagged 1 are the cause of Alagille syndrome type 1 (ALGS1). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. Defects in JAG1/Jagged 1 are also a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation.