|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CTHRC1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11647-ACG|
|Human CTHRC1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11647-ACR|
|Human CTHRC1 ORF mammalian expression plasmid, C-Flag tag||HG11647-CF|
|Human CTHRC1 ORF mammalian expression plasmid, C-His tag||HG11647-CH|
|Human CTHRC1 ORF mammalian expression plasmid, C-Myc tag||HG11647-CM|
|Human CTHRC1 ORF mammalian expression plasmid, C-HA tag||HG11647-CY|
|Human CTHRC1 Gene cDNA clone plasmid||HG11647-M|
|Human CTHRC1 ORF mammalian expression plasmid, N-Flag tag||HG11647-NF|
|Human CTHRC1 ORF mammalian expression plasmid, N-His tag||HG11647-NH|
|Human CTHRC1 ORF mammalian expression plasmid, N-Myc tag||HG11647-NM|
|Human CTHRC1 ORF mammalian expression plasmid, N-HA tag||HG11647-NY|
|Human CTHRC1 natural ORF mammalian expression plasmid||HG11647-UT|
|Learn more about expression Vectors|
Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.