|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human ESM1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11578-ACG|
|Human ESM1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11578-ACR|
|Human ESM1 ORF mammalian expression plasmid, C-Flag tag||HG11578-CF|
|Human ESM1 ORF mammalian expression plasmid, C-His tag||HG11578-CH|
|Human ESM1 ORF mammalian expression plasmid, C-Myc tag||HG11578-CM|
|Human ESM1 ORF mammalian expression plasmid, C-HA tag||HG11578-CY|
|Human ESM1 Gene cDNA clone plasmid||HG11578-M|
|Human ESM1 ORF mammalian expression plasmid, N-Flag tag||HG11578-NF|
|Human ESM1 ORF mammalian expression plasmid, N-His tag||HG11578-NH|
|Human ESM1 ORF mammalian expression plasmid, N-Myc tag||HG11578-NM|
|Human ESM1 ORF mammalian expression plasmid, N-HA tag||HG11578-NY|
|Human ESM1 natural ORF mammalian expression plasmid||HG11578-UT|
|Learn more about expression Vectors|
ESM1 is a secreted protein which is produced by adipocytes. It has been noticed that ESM1 may play some role in obesity-associated vascular disease since circulating ESM-1 levels are reduced in the overweight and obese. ESM1 is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Recently, ESM1 has been described as a specific biomarker of tip cells during neoangiogenesis. Its expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF or FGF-2. In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against ESM1.