|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human QPCT ORF mammalian expression plasmid, C-GFPSpark tag||HG13752-ACG|
|Human QPCT ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13752-ACR|
|Human QPCT ORF mammalian expression plasmid, C-Flag tag||HG13752-CF|
|Human QPCT ORF mammalian expression plasmid, C-His tag||HG13752-CH|
|Human QPCT ORF mammalian expression plasmid, C-Myc tag||HG13752-CM|
|Human QPCT ORF mammalian expression plasmid, C-HA tag||HG13752-CY|
|Human QPCT Gene cDNA clone plasmid||HG13752-G|
|Human QPCT ORF mammalian expression plasmid, N-Flag tag||HG13752-NF|
|Human QPCT ORF mammalian expression plasmid, N-His tag||HG13752-NH|
|Human QPCT ORF mammalian expression plasmid, N-Myc tag||HG13752-NM|
|Human QPCT ORF mammalian expression plasmid, N-HA tag||HG13752-NY|
|Human QPCT natural ORF mammalian expression plasmid||HG13752-UT|
|Learn more about expression Vectors|
Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and deletions, particularly in the active-site region. Glutaminyl cyclase's amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. It is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides.