|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human SDC1 ORF mammalian expression plasmid, C-GFPSpark tag||HG11429-ACG|
|Human SDC1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG11429-ACR|
|Human SDC1 ORF mammalian expression plasmid, C-Flag tag||HG11429-CF|
|Human SDC1 ORF mammalian expression plasmid, C-His tag||HG11429-CH|
|Human SDC1 ORF mammalian expression plasmid, C-Myc tag||HG11429-CM|
|Human SDC1 ORF mammalian expression plasmid, C-HA tag||HG11429-CY|
|Human SDC1 Gene cDNA clone plasmid||HG11429-M|
|Human SDC1 ORF mammalian expression plasmid, His tag||HG11429-M-H|
|Human SDC1 ORF mammalian expression plasmid, N-Flag tag||HG11429-NF|
|Human SDC1 ORF mammalian expression plasmid, N-His tag||HG11429-NH|
|Human SDC1 ORF mammalian expression plasmid, N-Myc tag||HG11429-NM|
|Human SDC1 ORF mammalian expression plasmid, N-HA tag||HG11429-NY|
|Human SDC1 natural ORF mammalian expression plasmid||HG11429-UT|
|Learn more about expression Vectors|
Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.