|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive ,Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
A myc tag is a polypeptide protein tag derived from the c-myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography, then used to separate recombinant, overexpressed protein from wild type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits.
A myc tag can be used in many different assays that require recognition by an antibody. If there is no antibody against the studied protein, adding a myc-tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by Western blotting.
The peptide sequence of the myc-tag is: N-EQKLISEEDL-C (1202 Da). It can be fused to the C-terminus and the N-terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway.
|Rat IL23R ORF mammalian expression plasmid, C-GFPSpark tag||RG80395-ACG|
|Rat IL23R ORF mammalian expression plasmid, C-OFPSpark / RFP tag||RG80395-ACR|
|Rat IL23R ORF mammalian expression plasmid, C-Flag tag||RG80395-CF|
|Rat IL23R ORF mammalian expression plasmid, C-His tag||RG80395-CH|
|Rat IL23R ORF mammalian expression plasmid, C-Myc tag||RG80395-CM|
|Rat IL23R ORF mammalian expression plasmid, C-HA tag||RG80395-CY|
|Rat IL23R Gene cDNA clone plasmid||RG80395-G|
|Rat IL23R ORF mammalian expression plasmid, N-Flag tag||RG80395-NF|
|Rat IL23R ORF mammalian expression plasmid, N-His tag||RG80395-NH|
|Rat IL23R ORF mammalian expression plasmid, N-Myc tag||RG80395-NM|
|Rat IL23R ORF mammalian expression plasmid, N-HA tag||RG80395-NY|
|Rat IL23R natural ORF mammalian expression plasmid||RG80395-UT|
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IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.