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Cynomolgus LFA-3 / CD58 Protein (His Tag)

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
Cynomolgus CD58 Protein Product Information
Synonym:CD58, LFA3
Protein Construction:A DNA sequence encoding the cynomolgus CD58 (F7HQR6) (Met1-Arg215) was expressed with a polyhistidine tag at the C-terminus.
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Cynomolgus CD58 Protein QC Testing
Purity:> 95 % as determined by SDS-PAGE
Bio-Activity:Measured by its binding ability in a functional ELISA.
Immobilized Cynomolgus CD58-His at 10 μg/ml (100 μl/well) can bind Cynomolgus CD2-Fc (Cat:90300-C02H), The EC50 of Cynomolgus CD2-Fc (Cat:90300-C02H) is 0.06-0.14 μg/ml.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Ile 29
Molecule Mass:The recombinant cynomolgus CD58 comprises 198 amino acids and has a calculated molecular mass of 23 KDa. The apparent molecular mass of it is approximately 38-42 KDa in SDS-PAGE under reducing conditions.
Formulation:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Cynomolgus CD58 Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Cynomolgus CD58 Protein SDS-PAGE
Cynomolgus LFA-3 / CD58 Protein (His Tag) SDS-PAGE
Cynomolgus LFA-3 / CD58 Protein (His Tag) SDS-PAGE
Other CD58 Recombinant Protein Products
LFA-3 / CD58 Background

CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

Cynomolgus LFA-3 / CD58 References
  • Rochelle JM. et al., 1993, Int Immunol. 5 (2): 209-16.
  • Virtaneva KI. et al., 1993, Immunogenetics. 37 (6): 461-5.
  • Horejsí V. et al., 1991, FEBS Lett. 288 (1-2): 1-4.
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    Catalog: 90190-C08H-50
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