|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human FGFRL1 ORF mammalian expression plasmid, C-GFPSpark tag||HG13589-ACG|
|Human FGFRL1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13589-ACR|
|Human FGFRL1 ORF mammalian expression plasmid, C-Flag tag||HG13589-CF|
|Human FGFRL1 ORF mammalian expression plasmid, C-His tag||HG13589-CH|
|Human FGFRL1 ORF mammalian expression plasmid, C-Myc tag||HG13589-CM|
|Human FGFRL1 ORF mammalian expression plasmid, C-HA tag||HG13589-CY|
|Human FGFRL1 Gene cDNA clone plasmid||HG13589-G|
|Human FGFRL1 ORF mammalian expression plasmid, N-Flag tag||HG13589-NF|
|Human FGFRL1 ORF mammalian expression plasmid, N-His tag||HG13589-NH|
|Human FGFRL1 ORF mammalian expression plasmid, N-Myc tag||HG13589-NM|
|Human FGFRL1 ORF mammalian expression plasmid, N-HA tag||HG13589-NY|
|Human FGFRL1 natural ORF mammalian expression plasmid||HG13589-UT|
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Fibroblast growth factor receptor-like 1 (FGFRL1) also known as Fibroblast growth factor receptor 5 (FGFR5), is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A unique feature of FGFRL1/FGFR5 is that it does not contain an intracellular tyrosine kinase domain. Some muscle types, including the muscles of the tongue and the diaphragm, express FGFRL1/FGFR5 at relatively high level. In contrast, the heart and the skeletal muscles of the limbs, as well as many other organs (brain, lung, liver, kidney, gut) express Fgfrl1 only at basal level. It is conceivable that FGFRL1/FGFR5 interacts with other Fgfrs, which are expressed in cartilage and muscle, to modulate FGF signaling.