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Cynomolgus Ephrin-A5 / EFNA5 Protein (His Tag)

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
EphrinA5/EFNA5Protein Product Information
Synonym:EFNA5
Protein Construction:A DNA sequence encoding the Cynomolgus EFNA5 (F7GZC7) (Met1-Asn203) was expressed, fused with a polyhistidine tag at the C-terminus.
Species:Cynomolgus
Expressed Host:Human Cells
Form & Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
EphrinA5/EFNA5Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE
Bio-Activity:Measured by its binding ability in a functional ELISA.
Immobilized Cynomolgus EFNA5-His at 10 μg/ml (100 μl/well) can bind Cynomolgus EFNA5-His (Cat:90039-C02H), The EC50 of Cynomolgus EFNA5-His (Cat:90039-C02H) is 14.8-34.7 ng/ml.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Ser 20
Molecule Mass:The recombinant Cynomolgus EFNA5 is a disulfide-linked homodimer. The reduced monomer comprises 194 amino acids and has a calculated molecular mass of 22.6 KDa. The apparent molecular mass of it is approximately 28 KDa respectively in SDS-PAGE.
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
EphrinA5/EFNA5Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
90044-C08H
Background

Ephrin-A5 also known as EFNA5, is a member of the Ephrin family. The Eph family receptor interacting proteins (ephrins) are a family of proteins that serve as the ligands of the Eph receptor, which compose the largest known subfamily of receptor protein-tyrosine kinases (RTKs). Ephrin subclasses are further distinguished by their mode of attachment to the plasma membrane: ephrin-A ligands bind EphA receptors and are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) linkage, whereas ephrin-B ligands bind EphB receptors and are anchored via a transmembrane domain. Ephrin-A5/EFNA5 may function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Ephrin-A5/EFNA5 also serves as a cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.

References
  • Frisén J, et al. (1998) Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 20(2): 235-43.
  • Feldheim DA, et al. (2000) Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25(3): 563-74.
  • Wahl S, et al. (2000) Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase. J Cell Biol. 149(2): 263-70.
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    Size / Price
    Catalog:90044-C08H-500
    List Price: $298.00  (Save $0.00)
    Price:$298.00      [How to order]
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    • Cynomolgus Ephrin-A5 / EFNA5 Protein (His Tag) SDS-PAGE
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