|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CDCP1 ORF mammalian expression plasmid, C-GFPSpark tag||HG13262-ACG|
|Human CDCP1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13262-ACR|
|Human CDCP1 ORF mammalian expression plasmid, C-Flag tag||HG13262-CF|
|Human CDCP1 ORF mammalian expression plasmid, C-His tag||HG13262-CH|
|Human CDCP1 ORF mammalian expression plasmid, C-Myc tag||HG13262-CM|
|Human CDCP1 ORF mammalian expression plasmid, C-HA tag||HG13262-CY|
|Human CDCP1 Gene cDNA clone plasmid||HG13262-G|
|Human CDCP1 ORF mammalian expression plasmid, N-Flag tag||HG13262-NF|
|Human CDCP1 ORF mammalian expression plasmid, N-His tag||HG13262-NH|
|Human CDCP1 ORF mammalian expression plasmid, N-Myc tag||HG13262-NM|
|Human CDCP1 ORF mammalian expression plasmid, N-HA tag||HG13262-NY|
|Human CDCP1 natural ORF mammalian expression plasmid||HG13262-UT|
|Learn more about expression Vectors|
CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.