|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human LAIR1 ORF mammalian expression plasmid, C-GFPSpark tag||HG13257-ACG|
|Human LAIR1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13257-ACR|
|Human LAIR1 ORF mammalian expression plasmid, C-Flag tag||HG13257-CF|
|Human LAIR1 ORF mammalian expression plasmid, C-His tag||HG13257-CH|
|Human LAIR1 ORF mammalian expression plasmid, C-Myc tag||HG13257-CM|
|Human LAIR1 ORF mammalian expression plasmid, C-HA tag||HG13257-CY|
|Human LAIR1 Gene cDNA clone plasmid||HG13257-G|
|Human LAIR1 ORF mammalian expression plasmid, N-Flag tag||HG13257-NF|
|Human LAIR1 ORF mammalian expression plasmid, N-His tag||HG13257-NH|
|Human LAIR1 ORF mammalian expression plasmid, N-Myc tag||HG13257-NM|
|Human LAIR1 ORF mammalian expression plasmid, N-HA tag||HG13257-NY|
|Human LAIR1 natural ORF mammalian expression plasmid||HG13257-UT|
|Learn more about expression Vectors|
Leukocyte associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and are able to spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells, but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.