|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human GDF-15 ORF mammalian expression plasmid, C-GFPSpark tag||HG10936-ACG|
|Human GDF-15 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10936-ACR|
|Human GDF-15 ORF mammalian expression plasmid, C-Flag tag||HG10936-CF|
|Human GDF-15 ORF mammalian expression plasmid, C-His tag||HG10936-CH|
|Human GDF-15 ORF mammalian expression plasmid, C-Myc tag||HG10936-CM|
|Human GDF-15 ORF mammalian expression plasmid, C-HA tag||HG10936-CY|
|Human GDF-15 Gene cDNA clone plasmid||HG10936-M|
|Human GDF-15 ORF mammalian expression plasmid, N-Flag tag||HG10936-NF|
|Human GDF-15 ORF mammalian expression plasmid, N-His tag||HG10936-NH|
|Human GDF-15 ORF mammalian expression plasmid, N-Myc tag||HG10936-NM|
|Human GDF-15 ORF mammalian expression plasmid, N-HA tag||HG10936-NY|
|Human GDF-15 natural ORF mammalian expression plasmid||HG10936-UT|
|Learn more about expression Vectors|
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.