|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human GM2A ORF mammalian expression plasmid, C-GFPSpark tag||HG13246-ACG|
|Human GM2A ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13246-ACR|
|Human GM2A ORF mammalian expression plasmid, C-Flag tag||HG13246-CF|
|Human GM2A ORF mammalian expression plasmid, C-His tag||HG13246-CH|
|Human GM2A ORF mammalian expression plasmid, C-Myc tag||HG13246-CM|
|Human GM2A ORF mammalian expression plasmid, C-HA tag||HG13246-CY|
|Human GM2A Gene cDNA clone plasmid||HG13246-G|
|Human GM2A ORF mammalian expression plasmid, N-Flag tag||HG13246-NF|
|Human GM2A ORF mammalian expression plasmid, N-His tag||HG13246-NH|
|Human GM2A ORF mammalian expression plasmid, N-Myc tag||HG13246-NM|
|Human GM2A ORF mammalian expression plasmid, N-HA tag||HG13246-NY|
|Human GM2A natural ORF mammalian expression plasmid||HG13246-UT|
|Learn more about expression Vectors|
GM2A (GM2 ganglioside activator), is a lipid transfer protein which belongs to the ML domain family. GM2A can accommodate several single chain phospholipids and fatty acids. It also exhibits some calcium-independent phospholipase activity. GM2A binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. GM2A acts as a substrate specific co-factor for the lysosomal enzyme β-hexosaminidase A. β-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB), also known as Tay-Sachs disease AB variant.