|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human OSTM1 ORF mammalian expression plasmid, C-GFPSpark tag||HG10913-ACG|
|Human OSTM1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10913-ACR|
|Human OSTM1 ORF mammalian expression plasmid, C-Flag tag||HG10913-CF|
|Human OSTM1 ORF mammalian expression plasmid, C-His tag||HG10913-CH|
|Human OSTM1 ORF mammalian expression plasmid, C-Myc tag||HG10913-CM|
|Human OSTM1 ORF mammalian expression plasmid, C-HA tag||HG10913-CY|
|Human OSTM1 Gene cDNA clone plasmid||HG10913-M|
|Human OSTM1 ORF mammalian expression plasmid, Flag tag||HG10913-M-F|
|Human OSTM1 ORF mammalian expression plasmid, N-Flag tag||HG10913-NF|
|Human OSTM1 ORF mammalian expression plasmid, N-His tag||HG10913-NH|
|Human OSTM1 ORF mammalian expression plasmid, N-Myc tag||HG10913-NM|
|Human OSTM1 ORF mammalian expression plasmid, N-HA tag||HG10913-NY|
|Human OSTM1 natural ORF mammalian expression plasmid||HG10913-UT|
|Learn more about expression Vectors|
Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has a important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).
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