|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human CXCL1 ORF mammalian expression plasmid, C-GFPSpark tag||HG10877-ACG|
|Human CXCL1 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10877-ACR|
|Human CXCL1 ORF mammalian expression plasmid, C-Flag tag||HG10877-CF|
|Human CXCL1 ORF mammalian expression plasmid, C-His tag||HG10877-CH|
|Human CXCL1 ORF mammalian expression plasmid, C-Myc tag||HG10877-CM|
|Human CXCL1 ORF mammalian expression plasmid, C-HA tag||HG10877-CY|
|Human CXCL1 Gene cDNA clone plasmid||HG10877-M|
|Human CXCL1 ORF mammalian expression plasmid, Flag tag||HG10877-M-F|
|Human CXCL1 ORF mammalian expression plasmid, N-Flag tag||HG10877-NF|
|Human CXCL1 ORF mammalian expression plasmid, N-His tag||HG10877-NH|
|Human CXCL1 ORF mammalian expression plasmid, N-Myc tag||HG10877-NM|
|Human CXCL1 ORF mammalian expression plasmid, N-HA tag||HG10877-NY|
|Human CXCL1 natural ORF mammalian expression plasmid||HG10877-UT|
|Learn more about expression Vectors|
The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.