|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human F3 ORF mammalian expression plasmid, C-GFPSpark tag||HG13133-ACG|
|Human F3 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG13133-ACR|
|Human F3 ORF mammalian expression plasmid, C-Flag tag||HG13133-CF|
|Human F3 ORF mammalian expression plasmid, C-His tag||HG13133-CH|
|Human F3 ORF mammalian expression plasmid, C-Myc tag||HG13133-CM|
|Human F3 ORF mammalian expression plasmid, C-HA tag||HG13133-CY|
|Human F3 Gene cDNA clone plasmid||HG13133-G|
|Human F3 ORF mammalian expression plasmid, N-Flag tag||HG13133-NF|
|Human F3 ORF mammalian expression plasmid, N-His tag||HG13133-NH|
|Human F3 ORF mammalian expression plasmid, N-Myc tag||HG13133-NM|
|Human F3 ORF mammalian expression plasmid, N-HA tag||HG13133-NY|
|Human F3 natural ORF mammalian expression plasmid||HG13133-UT|
|Learn more about expression Vectors|
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions.