|Datasheet||Specific References||Reviews||Related Products||Protocols|
|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Human FGFR2 ORF mammalian expression plasmid, C-GFPSpark tag||HG10824-ACG|
|Human FGFR2 ORF mammalian expression plasmid, C-OFPSpark / RFP tag||HG10824-ACR|
|Human FGFR2 ORF mammalian expression plasmid, C-Flag tag||HG10824-CF|
|Human FGFR2 ORF mammalian expression plasmid, C-His tag||HG10824-CH|
|Human FGFR2 ORF mammalian expression plasmid, C-Myc tag||HG10824-CM|
|Human FGFR2 ORF mammalian expression plasmid, C-HA tag||HG10824-CY|
|Human FGFR2 Gene cDNA clone plasmid||HG10824-M|
|Human FGFR2 ORF mammalian expression plasmid, N-Flag tag||HG10824-NF|
|Human FGFR2 ORF mammalian expression plasmid, N-His tag||HG10824-NH|
|Human FGFR2 ORF mammalian expression plasmid, N-Myc tag||HG10824-NM|
|Human FGFR2 ORF mammalian expression plasmid, N-HA tag||HG10824-NY|
|Human FGFR2 natural ORF mammalian expression plasmid||HG10824-UT|
|Learn more about expression Vectors|
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.